Journal
NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY
Volume 3, Issue 9, Pages 516-525Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncpgasthep0582
Keywords
celiac disease; gluten; major histocompatibility complex; natural killer receptors; transglutaminase
Categories
Funding
- NIDDK NIH HHS [R01 DK 58727, R01 DK 063158, P30 DK 42086] Funding Source: Medline
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Celiac disease is a genetic inflammatory disorder with autoimmune components that is induced by the ingestion of dietary gluten. Refractory sprue and enteropathy-associated T-cell lymphoma are rare but distinctive complications of the disease. Although the importance of the adaptive immune response to gluten has been well established, observations now also point towards a central role for the gluten-induced innate stress response in the pathogenesis of celiac disease and its malignant complications.
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