Journal
BIOLOGY OF THE CELL
Volume 98, Issue 9, Pages 547-555Publisher
WILEY
DOI: 10.1042/BC20060025
Keywords
cell adhesion; cell migration; focal adhesion kinase (FAK); GTPase; integrin; phosphoinositide 3-kinase (PI3K)
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Funding
- NIGMS NIH HHS [1U54 GM64346] Funding Source: Medline
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Migrating cells tend to continue moving in the same direction, a property called persistence. During migration, cells, by definition, form new adhesions at their front and break old adhesions at the rear. We hypothesize that the distinction between new adhesions at the front and older adhesions at the rear plays a major role in directional persistence. We propose specific mechanisms of persistence on the basis of known properties of integrin signals, in hope of stimulating investigation of these ideas.
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