Journal
ANNALS OF EPIDEMIOLOGY
Volume 20, Issue 2, Pages 92-98Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.annepidem.2009.11.010
Keywords
Allergies; Diabetes; Multicenter Case-Control Study; Pancreas Cancer; Pancreatitis; Past Medical History
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Funding
- Ministry of Welfare, Health and Culture (formerly the Ministry of Health and Environmental Hygiene) of The Netherlands [808]
- Cancer Research Society
- Fondation Hotel Dieu de Montreal
- Fonds de la Recherche en Sante du Quebec
- National Cancer Institute of Canada
- C.D. Smithers Foundation
- Solvay Pharmaceuticals
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PURPOSE: To investigate risk factors that may be linked to pancreatic cancer. METHODS: We designed a multicenter population-based case control (823 cases, 1679 control patients) study with data collection by using a common protocol and questionnaire. Participating centers were located in Australia, Canada, the Netherlands, and Poland. RESULTS: After adjustment for confounding factors, a positive history of pancreatitis was associated with pancreatic cancer (odds ratio [OR], 4.68; 95% confidence interval [95% CI], 2.23-9.84). The risk was especially high in heavy smokers (OR, 15.4; 95% CI, 3.18-74.9). Patients with diabetes had an increased risk of developing pancreatic cancer (OR, 2.16; 95% CI, 1.60-2.91). The risk was highest in the first year after the development of diabetes (OR, 6.68; 95% CI, 3.56-12.6) and decreased over time. A history of allergy was associated with a reduced risk of pancreas cancer (OR, 0.64; 95% CI, 0.50-0.82). CONCLUSIONS: Patients with newly diagnosed diabetes and patients with pancreatitis, particularly in heavy smokers, have an increased risk for developing pancreatic cancer. In addition to being risk factors, these conditions could be early manifestations of underlying pancreatic cancer. A history of allergy decreases the risk of pancreatic cancer. Ann Epidemiol 2010;20:92-98. (C) 2010 Elsevier Inc. All rights reserved.
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