Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Volume 1760, Issue 9, Pages 1293-1297Publisher
ELSEVIER
DOI: 10.1016/j.bbagen.2006.06.006
Keywords
cardiomyocytes; cell growth; hypoxia; MEK/ERK; Rb
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The effects of short time (15 min) exposure to hypoxia on rat cardiomyocytes (H9c2) were examined. Exposure to hypoxia inhibited cell death via activation of MEK/extracellular signal-regulated kinase (ERK). Further, exposure to hypoxia promoted cell growth by down-regulation of p27 and phosphorylation of cyclin-dependent kinase 2 (CDK2) and retinoblastoma protein (Rb). (c) 2006 Elsevier B.V. All rights reserved.
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