Journal
JOURNAL OF DRUG TARGETING
Volume 14, Issue 8, Pages 519-526Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10611860600834409
Keywords
gene delivery; polyplexes; polycations; glutathione
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Funding
- NCI NIH HHS [CA109711] Funding Source: Medline
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< p > Polyplexes sensitive to redox potential gradients represent a promising class of vectors for delivery of nucleic acids. This review focuses on the recent advances in the development of these vectors. The biological rationale for the design of redox-sensitive polyplexes is discussed together with the basic synthetic approaches for introducing reducible disulfide bonds into the structure of the polyplexes. The biological properties of the redox-sensitive polyplexes of plasmid DNA, mRNA, antisense oligonucleotides and siRNA are reviewed with emphasis on < i > in vitro cellular delivery, cytotoxicity and < i > in vivo activity. Overall, redox-sensitive polyplexes represent a promising platform for further development as vectors for delivery of a wide variety of therapeutic nucleic acids.
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