4.4 Article

Pulmonary lymphatics are primary sites of Mycobacterium tuberculosis infection in guinea pigs infected by aerosol

Journal

INFECTION AND IMMUNITY
Volume 74, Issue 9, Pages 5397-5401

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.00332-06

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Funding

  1. NIAID NIH HHS [R01 AI054697, AI 054697] Funding Source: Medline

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Mycobacterium tuberculosis causes a lymphatic vasculitis in the lungs of guinea pigs infected by a low-dose aerosol. This observation suggests that in addition to being a direct conduit from the lungs to the regional lymph nodes, pulmonary lymphatics are themselves sites of infection and could be the site of latent infection.

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