Journal
DEVELOPMENTAL DYNAMICS
Volume 235, Issue 9, Pages 2507-2520Publisher
WILEY
DOI: 10.1002/dvdy.20891
Keywords
Chordin; Noggin; BMP; neural crest
Categories
Funding
- NICHD NIH HHS [HD39948, P01 HD039948, P01HD39948] Funding Source: Medline
- NIDCR NIH HHS [R56 DE013674, R01DE13674, DE13674, R01 DE013674, R01 DE013674-06] Funding Source: Medline
- NINDS NIH HHS [F31 NS042486-03, F31 NS042486-02, F31 NS042486-01, F31 NS042486] Funding Source: Medline
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We demonstrate here that Chordin and Noggin function as bone morphogenetic protein (BMP) antagonists in vivo to promote mammalian neural crest development. Using Chrd and Nog single and compound mutants, we find that Noggin has a major role in promoting neural crest formation, in which Chordin is partially redundant. BMP signaling is increased in dorsal tissues lacking Noggin and is further increased when Chordin is also absent. The early neural crest domain is expanded with decreased BMP antagonism in vivo. Noggin and Chordin also regulate subsequent neural crest cell emigration from the neural tube. However, reduced levels of these BMP antagonists ultimately result in perturbation of neural crest cell derived peripheral nervous system and craniofacial skeletal elements. Such defects reflect, at least in part, a function to limit apoptosis in neural crest cells. Noggin and Chordin, therefore, function together to regulate both the generation and survival of neural crest cells in mammalian development.
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