Journal
CLINICAL ORAL INVESTIGATIONS
Volume 10, Issue 3, Pages 205-209Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00784-006-0050-7
Keywords
verrucous carcinoma; oral squamous cell carcinoma; oral cancer; verrucous lesion; prognosis
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Funding
- FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) [03/14141-3]
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
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Oral verrucous carcinoma (OVC) is a rare variant of squamous cell carcinoma with a characteristic morphology and specific behavior. To date, few studies are available focusing the prevalence and clinicopathologic features of the oral verrucous carcinoma in Brazilian population. A total of 3,500 primary oral well-differentiated squamous cell carcinoma surgically excised in the A.C. Camargo Cancer Hospital and Amaral Carvalho Cancer Hospital, Brazil, from 1980 to 2000 were retrospectively reviewed. Twenty cases of verrucous carcinomas were identified, most of them occurring in older male with age above the sixth decade, the sites frequently affected being the lower lip and the hard palate. Microscopically, the tumor showed a heavily keratinized lesion with compressive invasion pattern, little atypia, and free surgical margins. The local recurrence was verified in 38.5% of the patients with oral verrucous carcinoma; however, regional recurrence and distant metastasis were not verified. The results suggest that, although it is less frequent and with excellent prognosis, the verrucous carcinoma presents a potential for local recurrence that should be considered during the surgical planning of this neoplasm in the oral cavity.
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