Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 61, Issue 9, Pages 907-917Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/61.9.907
Keywords
-
Categories
Ask authors/readers for more resources
Few studies to date have examined age-related changes in markers of immune status in healthy older individuals. The immune status of 93 healthy individuals aged 55-70 years was assessed by two- and three-color flow cytometry and biochemical analysis. There were significant age effects (p <= .05) on monocyte phagocytic activity and cluster of differentiation (CD) 3/human leukocyte antigen-D-related (HLA-DR) late-activated T lymphocytes (% expression). There was a significant (p <= 0.1) Age X Sex interaction in absolute counts (X 10(9)/L) of CD3/CD8 total cytotoxic T lymphocytes (CTL), the CD4 T-helper to CD8 CTL ratio, the CD3/CD4/CD45RA naive T helper to CD3/CD4/CD45RO memory T helper lymphocyte ratio, and interleukin (1L)-1 beta (% expression) by activated monocytes. The study shows that alterations in markers of immune status occur between 55 and 70 years, and provides reference values for the lymphocyte measures in healthy men and postmenopausal women in this age group. The study further highlights the need for sex-specific reference ranges for such markers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available