Journal
MICROBIOLOGY-SGM
Volume 152, Issue -, Pages 2717-2725Publisher
MICROBIOLOGY SOC
DOI: 10.1099/mic.0.28993-0
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Funding
- NIAID NIH HHS [AI46582, AI35272, R01 AI046582, R01 AI035272] Funding Source: Medline
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Mycobacterium tuberculosis under stress stores triacylglycerol (TG). There are 15 genes in M. tuberculosis that belong to a novel family of TG synthase genes (tgs), but it is not known which of them is responsible for this accumulation of TG. In this paper, it is reported that M. tuberculosis H37Rv accumulated TG under acidic, static or hypoxic growth conditions, or upon treatment with NO, whereas TG accumulation was drastically reduced in the tgs1 (Rv3130c) disrupted mutant. Complementation with tgs1 restored this TG accumulation. C-26 was a major fatty acid in this TG, indicating that the TGS1 gene product uses C-26 fatty acid, which is known to be produced by the mycobacterial fatty acid synthase. TGS1 expressed in Escherichia coli preferred C-26:0-CoA for TG synthesis. If TG storage is needed for the long-term survival of M. tuberculosis under dormant conditions, the tgs1 product could be a suitable target for antilatency drugs.
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