Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 36, Issue 9, Pages 2394-2400Publisher
WILEY
DOI: 10.1002/eji.200636290
Keywords
cytokines; dendritic cells; human natural killer cells; Th1/Th2 cells
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Funding
- NCI NIH HHS [R01CA108609] Funding Source: Medline
- NCRR NIH HHS [M01-RR00102] Funding Source: Medline
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Human secondary lymphoid tissues harbor NK cells that predominantly secrete cytokines in response to activation. Here, we demonstrate that these immunoregulatory NK cells assist in the Th1 polarization of primary immune responses, induced by dendritic cells. Tonsilar, but not peripheral blood NK cells enhanced the expansion of IFN-gamma-producing CD4(+) T cells via their superior ability to produce IFN-gamma. Addition of IFN-gamma increased Th1 polarization while antibody blocking of this cytokine abolished NK cell-dependent Th1 polarization. Our data suggest that NK cells in secondary lymphoid organs assist priming of Th1 cells via cytokine secretion and this effect should be harnessed during vaccination against viruses and tumors.
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