Journal
EXPERIMENTAL LUNG RESEARCH
Volume 32, Issue 8, Pages 379-393Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/01902140600880257
Keywords
lipofibroblast; lung fibroblast; myofibroblast; parathyroid hormone-related protein; peroxisome proliferator-activated receptor gamma
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Funding
- NHLBI NIH HHS [HL55268, HL75405] Funding Source: Medline
- NIGMS NIH HHS [1R25 GM56902] Funding Source: Medline
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The lipid-containing alveolar interstitial fibroblast (lipofibroblast) is known to be critically involved in rodent lung development, homeostasis, and injury/repair. However, there is lack of information on their presence and function in the human lung. Based on a number of morphological (lipid staining), molecular (presence of characteristic lipogenic and absence of myogenic markers), and functional (triglyceride uptake) characteristics that are the hallmarks of the rodent lung lipofibroblast, using human lung fibroblasts of embryonic (WI-38) and adult origin and lung tissue from human autopsy specimens, the authors for the first time clearly demonstrate the presence of lipofibroblasts in the human lung.
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