Journal
LEUKEMIA & LYMPHOMA
Volume 47, Issue 9, Pages 1774-1781Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428190600678975
Keywords
chronic myeloproliferative disorders; bone marrow histology
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We reviewed a large series of patients with essential thrombocythemia diagnosed on the basis of the Polycythemia Vera Study Group criteria, and reclassified them by evaluating their major morphologic features and clinical course using the World Health Organization classification. The morphologic review of the bone marrow biopsies of 116 patients ( 44 males and 72 females; aged 19-83 years, median 55 years; median follow-up 121 months) led to 22 cases (19%) being classified as essential thrombocythemia (ET), 24 (21%) as chronic idiopathic myelofibrosis (CIMF)- 0, 44 (37%) as CIMF-1, 13 (12%) as CIMF-2, 9 (8%) as latent phase polycythemia vera, and four (3%) as chronic myeloproliferative disorder, unclassifiable. There was a significant difference in the median age of the ET and fibrotic CIMF patients (54.7 +/- 13.55 vs. 59.13 +/- 15.05 years; P =0.03). Histologic analysis showed that the simultaneous presence of loose clusters of large/ giant megakaryocytes and nuclear hyperlobulation was significantly different between the ET and the prefibrotic CIMF (P < 0.01) and fibrotic CIMF patients (P < 0.01), and that the association of dense clusters of megakaryocytes with maturation defects and bulbous nuclei also distinguished the prefibrotic CIMF (P < 0.05) and fibrotic CIMF patients (P < 0.001) from those with ET. The association of cellularity, granulocytic proliferation and reticulin fibers was helpful in distinguishing prefibrotic from fibrotic CIMF (P < 0.001).
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