Journal
NATURE MEDICINE
Volume 12, Issue 9, Pages 1023-1026Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm1462
Keywords
-
Funding
- MRC [G19/34] Funding Source: UKRI
- Medical Research Council [G0800766, G19/34] Funding Source: Medline
- NIAID NIH HHS [R01 AI051139, AI057468, AI051139, R01 AI057468] Funding Source: Medline
- Medical Research Council [G19/34] Funding Source: researchfish
Ask authors/readers for more resources
Rhinoviruses are the major cause of asthma exacerbations, and asthmatics have increased susceptibility to rhinovirus and risk of invasive bacterial infections. Here we show deficient induction of interferon-lambda s by rhinovirus in asthmatic primary bronchial epithelial cells and alveolar macrophages, which was highly correlated with severity of rhinovirus-induced asthma exacerbation and virus load in experimentally infected human volunteers. Induction by lipopolysaccharide in asthmatic macrophages was also deficient and correlated with exacerbation severity. These results identify previously unknown mechanisms of susceptibility to infection in asthma and suggest new approaches to prevention and/or treatment of asthma exacerbations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available