Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 50, Issue 9, Pages 3154-3156Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00774-05
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Funding
- Wellcome Trust [GR067910MA] Funding Source: Medline
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Nonlinear mixed-effects analysis of serial sputum colony-counting data supports the existence of two bacillary subpopulations in sputum, eliminated at different rates. It distinguishes between combination regimens, removes bias, and greatly improves precision, with significant implications for the analysis of surrogate endpoints of sterilization in the development of new antituberculosis regimens.
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