Journal
NATURE CELL BIOLOGY
Volume 8, Issue 9, Pages 1035-U120Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb1467
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Funding
- Wellcome Trust [075744] Funding Source: Medline
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Separase not only triggers anaphase of meiosis I by proteolytic cleavage of cohesin on chromosome arms, but in vitro vertebrate separase also acts as a direct inhibitor of cyclin-dependent kinase 1 (Cdk1) on liberation from the inhibitory protein, securin. Blocking separase-Cdk1 complex formation by microinjection of anti-separase antibodies prevents polarbody extrusion in vertebrate oocytes. Importantly, proper meiotic maturation is rescued by chemical inhibition of Cdk1 or expression of Cdk1-binding separase fragments lacking cohesin-cleaving activity.
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