Journal
DEVELOPMENTAL CELL
Volume 11, Issue 3, Pages 339-348Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2006.06.015
Keywords
-
Categories
Funding
- NCI NIH HHS [R01 CA78711] Funding Source: Medline
- NIDDK NIH HHS [K01 DK064063] Funding Source: Medline
- NIGMS NIH HHS [R01GM36477] Funding Source: Medline
Ask authors/readers for more resources
While particular combinations of mesodermal signals are known to induce distinct tissue-specific programs in the endoderm, there is little information about the response pathways within endoderm cells that control their specification. We have used signaling inhibitors on embryo tissue explants and whole-embryo cultures as well as genetic approaches to reveal part of an intracellular network by which FGF signaling helps induce hepatic genes and stabilize nascent hepatic cells within the endodermal epithelium. Specifically, we found that hepatic gene induction is elicited by an FGF/MAPK pathway. Although the PI3K pathway is activated in foregut endoderm cells, its inhibition does not block hepatic gene induction in explants; however, it does block tissue growth. We also found that at the onset of hepatogenesis, the FGF/MAPK and PI3K pathways do not crossregulate in the endoderm. The finding of separate pathways for endoderm tissue specification and growth provides insights for guiding cellular regeneration and stem cell differentiation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available