Journal
EUROPEAN JOURNAL OF CANCER
Volume 42, Issue 14, Pages 2335-2342Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2006.03.023
Keywords
temozolomide; metronomic; brain tumour; child; dose escalation
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The aims of this study were to determine the maximum tolerated dose (MTD), toxicity and pharmacokinetics of oral temozolomide administered over 42 d in children with recurrent/ refractory brain tumours. Cohorts of 3-6 patients were treated for 42 d, followed by a 7-d rest period for a maximum of 6 cycles. Patients were stratified as heavily pre-treated (HPT) and non-heavily pre-treated (NHPT). Starting doses were 50 mg/m(2) (HPT) or 75 mg/m(2) (NHPT). Out of 28 patients enrolled, 20 were evaluable for toxicity and 19 for pharmacokinetics. Three patients in the NHPT group developed grade 3/4 haematological toxicity, 2 experienced dose-limiting toxicity (thrombocytopenia) at 100 mg/m(2), and 9/20 developed grade 3 lymphopenia. MTD in both strata was 85 mg/m(2). Responses were observed in 4 patients: 2 complete responses (CR) in medulloblastoma and supratentorial primitive neuroectodermal tumours (PNET), and 2 partial responses (PR) in high-grade glioma, respectively. Overall cumulative exposure was at least 1.5 times higher than in the 5-d administration schedule. In conclusion, the recommended dose of temozolomide is 85 mg/m(2) x 42 d. Dose-limiting toxicities are thrombocytopenia and lymphopenia. The observed response rate warrants phase II studies. (c) 2006 Elsevier Ltd. All rights reserved.
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