Journal
SCIENCE
Volume 313, Issue 5791, Pages 1301-1303Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1127704
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The early morphogenetic mechanisms involved in heart formation are evolutionarily conserved. A screen for genes that control Drosophila heart development revealed a cardiac defect in which pericardial and cardial cells dissociate, which causes loss of cardiac function and embryonic lethality. This phenotype resulted from mutations in the genes encoding HMG-CoA reductase, downstream enzymes in the mevalonate pathway, and G protein G gamma 1, which is geranylgeranylated, thus representing an end point of isoprenoid biosynthesis. Our findings reveal a cardial cell-autonomous requirement of G gamma 1 geranylgeranylation for heart formation and suggest the involvement of the mevalonate pathway in congenital heart disease.
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