Journal
EUROPEAN JOURNAL OF CELL BIOLOGY
Volume 85, Issue 9-10, Pages 897-904Publisher
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2006.06.003
Keywords
Dictyostelium discoideum; phosphoinositides; PI3K; PTEN; chemotaxis; cell migration; G proteins; G protein-coupled receptor; cAMP
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Funding
- NIGMS NIH HHS [GM34933, GM28007, R01 GM028007] Funding Source: Medline
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Chemotaxis, or cell migration guided by chemical cues, is critical for a multitude of biological processes in a diverse array of organisms. Dictyostelium discoideum amoebae rely on chemotaxis to find food and to survive starvation conditions, and we have taken advantage of this system to study the molecular regulation of this vital cell behavior. Previous work has identified phosphoinositide signaling as one mechanism which may contribute to directional sensing and actin polymerization during chemotaxis; a mechanism which is conserved in mammalian neutrophils. In this review, we will discuss recent data on genes and pathways governing directional sensing and actin polymerization, with a particular emphasis on contributions from our laboratory. (c) 2006 Elsevier GmbH. All rights reserved.
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