Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 65, Issue 1, Pages 169-172Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2005.09.045
Keywords
gossypol; beta-cyclodextrin; inclusion complex; fluorescence; scanning electron microscopy
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Features of the inclusion complex between gossypol (Gos) and beta-cyclodextrin (CD), such as its aqueous solubility, association constant, characteristics in the solid state and crystalline morphology, as well as the stoichiometry of this complex have been determined. The phase-solubility diagram drawn using UV detections belongs to an AN-type. Fluorescence detection and calculation with the modified Benesi-Hidebrond equation provide an 1:2 stoichiometry for the complex. Its apparent stability constant has been determined to be 3203 M-1 by fluorescence technique and confirmed by the calculation from UV spectroscopy. X-ray powder diffractions (XRD) and Scanning Electron Microscopy (SEM) observations showed a clear difference in the crystal morphology of the complex from those of both Gos and beta-CD. (c) 2005 Elsevier B.V. All rights reserved.
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