Journal
ANNALS OF BIOMEDICAL ENGINEERING
Volume 34, Issue 9, Pages 1475-1482Publisher
SPRINGER
DOI: 10.1007/s10439-006-9160-2
Keywords
constitutive modeling; matrix mechanics; cell mechanics
Categories
Funding
- NHLBI NIH HHS [K25 HL079165] Funding Source: Medline
- NIAMS NIH HHS [R01 AR047591, AR47591] Funding Source: Medline
- NIGMS NIH HHS [GM38838] Funding Source: Medline
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The mechanics of bio-artificial tissue constructs result from active and passive contributions of cells and extracellular matrix (ECM). We delineated these for a fibroblast-populated matrix (FPM) consisting of chick embryo fibroblast cells in a type I collagen ECM through mechanical testing, mechanical modeling, and selective biochemical elimination of tissue components. From a series of relaxation tests, we found that contributions to overall tissue mechanics from both cells and ECM increase exponentially with the cell concentration. The force responses in these relaxation tests exhibited a logarithmic decay over the 3600 second test duration. The amplitudes of these responses were nearly linear with the amplitude of the applied stretch. The active component of cellular forces rose dramatically for FPMs containing higher cell concentrations.
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