Journal
JOURNAL OF ANTIBIOTICS
Volume 59, Issue 9, Pages 553-563Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2006.76
Keywords
fungi; Beauveria felina; marine microorganisms; destruxins
Funding
- NCI NIH HHS [CA36622] Funding Source: Medline
- NCRR NIH HHS [RR06262, RR13030] Funding Source: Medline
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Chemical investigation of the cytotoxic and anti-tuberculosis active butanone extract obtained from the growth media of the marine-derived fungus Beauveria felina led to the isolation of two new destruxins, [P-MePro] destruxin E chlorohydrin (1) and pseudodestruxin C (3), along with five known cyclic depsipeptides. The structures of the new destruxin derivatives were established by analysis of spectroscopic data, while the absolute configuration of the common amino acid residues was established by Marfey's analysis. The absolute configuration of the 2(R),4(S)-5-chloro-2,4-dihydroxypentanoic acid residue in I could be established by application of a J-based configuration method followed by derivatization with R-MPA-Cl and NMR analysis.
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