Journal
NEUROSCIENCE LETTERS
Volume 404, Issue 3, Pages 262-265Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2006.06.015
Keywords
VGLUT1; VGLUT2; glutamate; platelet release; human platelets
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Vesicular glutamate transporters (VGLUTs) are involved in storing glutamate for secretion at the level of glutamatergic axon terminals, and for this reason they have been extensively used as markers to identify glutamate-releasing cells. Platelets have been considered as a suitable model for studying glutamatergic dysfunction because they perform glutamate uptake and express both external transporters, and NMDA-like receptors. Here, we show that platelets express the pre-synaptic markers VGLUT1 and VGLUT2 and release glutamate following aggregation, implying a possible contributory role in the pathophysiology of stroke, migraine, and other excitotoxic disorders. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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