Journal
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
Volume 1, Issue 3, Pages 305-316Publisher
SPRINGER
DOI: 10.1007/s11481-006-9022-6
Keywords
Ca2+; G-protein coupled receptors; matrix metalloprotease; NO (nitric oxide); ONOO- (peroxynitrite); S-nitrosylation
Categories
Funding
- NIDA NIH HHS [U24 DA012385, U24-DA12385, R01 DA003690, R01-DA03690] Funding Source: Medline
- NIGMS NIH HHS [S06 GM08049] Funding Source: Medline
- NIMHD NIH HHS [P20-MD00175] Funding Source: Medline
- PHS HHS [K05-00182] Funding Source: Medline
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Neuropathologies that affect our population include ischemic stroke and neurodegenerative diseases of immune origin, including multiple sclerosis. The endocannabinoid system in the brain, including agonists anandamide (arachidonyl ethanolamide) and 2-arachidonoylglycerol, and the CB1 and CB2 cannabinoid receptors, has been implicated in the pathophysiology of these disease states, and can be a target for therapeutic interventions. This review concentrates on cellular signal transduction pathways believed to be involved in the cellular damage.
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