Journal
JOURNAL OF PROTEOME RESEARCH
Volume 5, Issue 9, Pages 2236-2240Publisher
AMER CHEMICAL SOC
DOI: 10.1021/pr0504485
Keywords
cancer; dichotomous development; mass spectrometry; phylogenetics; phyloproteomics; proteomics; serum; transitional clades
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Funding
- Intramural NIH HHS [Z99 CA999999] Funding Source: Medline
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Phyloproteomics is a novel analytical tool that solves the issue of comparability between proteomic analyses, utilizes a total spectrum-parsing algorithm, and produces biologically meaningful classification of specimens. Phyloproteomics employs two algorithms: a new parsing algorithm (UNIPAL) and a phylogenetic algorithm (MIX). By outgroup comparison, the parsing algorithm identifies novel or vanished MS peaks and peaks signifying up or down regulated proteins and scores them as derived or ancestral. The phylogenetic algorithm uses the latter scores to produce a biologically meaningful classification of the specimens.
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