Journal
JOURNAL OF IMMUNOLOGY
Volume 177, Issue 5, Pages 3074-3081Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.177.5.3074
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Funding
- Medical Research Council [G9818340, G0401620] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- MRC [G9818340, G0401620] Funding Source: UKRI
- Medical Research Council [G9818340, G0401620] Funding Source: researchfish
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We report here the quantitative expression of a set of immunity-related genes, including TNF family members, chemokine receptors, and transcription factors, in a CD4(+)CD3(-) accessory cell. By correlating gene expression between cell-sorted populations of defined phenotype, we show that the genetic fingerprint of these CD4(+)CD3(-) cells is distinct from dendritic cells, plasmacytoid dendritic cells, T cells, B cells, and NK cells. In contrast, it is highly similar to CD4(+)CD3(-) cells isolated from embryonic and neonatal tissues, with the exception that only adult populations express OX40L and CD30L. We have previously reported that IL-7 signals regulate CD30L expression. In the present study, we show that both neonatal and adult CD4(+)CD3(-) cells express the TNF family member, death receptor 3 (TNFRSF25), and that addition of TL1A (TNFSF15), the ligand for death receptor 3, up-regulates OX40L on neonatal CD4(+)CD3(-) cells. Finally, we demonstrate that this differentiation occurs in vivo: neonatal CD4(+)CD3(-) cells up-regulate both CD30L and OX40L after adoptive transfer into an adult recipient.
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