Journal
HORMONE AND METABOLIC RESEARCH
Volume 38, Issue 9, Pages 570-574Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2006-950503
Keywords
TNF alpha; p8 expression; com1; Nupr1; NF kappa B; inflammation
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p8 is a widely expressed HMG-I/Y-like transcription factor which is involved in regulating cell proliferation and tissue stress. Several studies describe a strong upregulation of p8 expression during inflammatory processes like pancreatitis and LPS-induced sepsis. Here we demonstrate that TNF alpha which is an important inducer of innate defence against gram-negative bacteria, significantly stimulates p8 protein production in H4IIE rat hepatoma cells within 2 hours. Since a putative NFKB motif has been described, we further tested whether TNF alpha stimulates p8 expression via activation of NFKB. We characterized the TNF alpha-induced binding of NFKB to this motif. We show that the TNF alpha-induced NFKB pathway contributes to the induction of p8 during pancreatitis and LPS-induced inflammation.
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