Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 56, Issue 3, Pages 585-592Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.20989
Keywords
magnetization transfer; amide proton exchange; MT; CEST; APT; brain tumor; protein
Funding
- NCI NIH HHS [CA92871] Funding Source: Medline
- NCRR NIH HHS [RR15241] Funding Source: Medline
- NIBIB NIH HHS [EB02634, EB02666, P41 EB015909] Funding Source: Medline
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Amide proton transfer (APT) imaging is a technique in which the nuclear magnetization of water-exchangeable amide protons of endogenous mobile proteins and peptides in tissue is saturated, resulting in a signal intensity decrease of the free water. In this work, the first human APT data were acquired from 10 patients with brain tumors on a 3T whole-body clinical scanner and compared with T-1- (T(1)w) and T-2-weighted (T(2)w), fluid-attenuated inversion recovery (FLAIR), and diffusion images (fractional anisotropy (FA) and apparent diffusion coefficient (ADC)). The APT-weighted images provided good contrast between tumor and edema. The effect of APT was enhanced by an approximate 4% change in the water signal intensity in tumor regions compared to edema and normal-appearing white matter (NAWM). These preliminary data from patients with brain tumors show that the APT is a unique contrast that can provide complementary information to standard clinical MRI measures.
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