Journal
XENOBIOTICA
Volume 36, Issue 9, Pages 824-837Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00498250600815906
Keywords
polybrominated diphenyl ethers (PBDEs); metabolism and disposition; persistent organic pollutants
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Funding
- Intramural NIH HHS [Z99 ES999999] Funding Source: Medline
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The disposition of the C-14-labelled polybrominated diphenyl ether (PBDE) 2,2',4,4',5,5'-hexaBDE (BDE153) was investigated in rodents following single and multiple doses and in a mixture with radiolabelled 2,2,4,4-tetraBDE (BDE47) and 2,2',4,4',5-pentaBDE (BDE99). In single exposure studies there was little or no effect of dose on BDE153 disposition in male rats in the range 1-100 mu mol kg(-1). No major sex or species differences in the in vivo fate of BDE153 were detected. BDE153 was absorbed in rats or mice following gavage by approximately 70%; retained in tissues; and poorly metabolized and slowly excreted. Mixture studies indicated that, relative to each other, more BDE47 was distributed to adipose tissue, more BDE153 accumulated in the liver, and BDE99 was metabolized to the greatest extent. BDE153 was probably retained in the liver due to minimal metabolism and elimination after 'first-pass' distribution to the tissue following gavage.
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