Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 6, Issue 9-10, Pages 3210-3214Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2006.469
Keywords
target drug delivery; magnetic hollow spheres; Layer-by-Layer; controlled release
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A novel controlled drug delivery system was fabricated by coating chitosan/PAA multilayer onto magnetic hollow spheres via a Layer-by-Layer (LBL) assembly approach. Cefradine was used as a model drug to evaluate the drug release characteristics of this core-shell hollow structure and the results show that it exhibits a sustained release of the drug and the release rate can be regulated by the pH environment of release medium. It is believed that this core-shell hollow structure, which combines the advantage of controlled delivery as well as magnetic targeting, has commendable potential in drug delivery therapeutics.
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