Journal
CLINICAL LUNG CANCER
Volume 8, Issue 2, Pages 116-121Publisher
CIG MEDIA GROUP, LP
DOI: 10.3816/CLC.2006.n.039
Keywords
cisplatin; esophagitis; etoposide; pneumonitis
Categories
Funding
- NCI NIH HHS [CA45560, CA45807, CA46113, CA46136, CA46282, CA46368, CA46441, CA52386, CA58415, CA58861, CA63844, CA67663, CA74647, CA 20319, CA76448, CA04919, CA12644, CA14028, CA15377, CA16385, CA20319, CA22433, CA32102, CA35119, CA35128, CA35176, CA35192, CA35261, CA45377, CA42777, CA38926, CA35431] Funding Source: Medline
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PURPOSE: Here we report 5-year survival data from S9504, a Southwest Oncology Group phase II trial evaluating consolidation docetaxel after concurrent cisplatin/etoposide and thoracic radiation therapy in patients with pathologically documented stage IIIB non-small-cell lung cancer. Survival outcomes were compared with a predecessor study (S9019) with identical eligibility, staging criteria, and treatment, excepting docetaxel consolidation. PATIENTS AND METHODS: Treatment consisted of cisplatin 50 mg/m(2) per day on days 1, 8, 29, and 36; etoposide 50 mg/m(2) per day on days 1-5 and 29-33; and concurrent thoracic radiation therapy (total dose, 61 Gy). Consolidation docetaxel (75 mg/m(2) initial dose) started 4-6 weeks after completion of chemotherapy. RESULTS: Concurrent chemotherapy was generally well tolerated, with a low level of radiationrelated esophagitis; 2 patients died from pneumonitis. Grade 3/4 neutropenia during consolidation docetaxel was common. At a median follow-up of 71 months, median progression-free survival was 16 months; median survival 26 months; and 3-, 4-, and 5-year survival rates were 40%, 29%, and 29%, respectively. Brain metastasis was the most common site of failure. In the predecessor trial S9019, median survival was 15 months, and 3-, 4-, and 5-year survival rates were 17%, 17%, and 17%, respectively. CONCLUSION: The 5-year survival rate in S9540 of 29% compares favorably with the predecessor trial S9019 and other treatment approaches currently used in this patient population. A phase III trial designed to validate the concept of consolidation docetaxel is presently under way.
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