Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 178, Issue 1-2, Pages 49-61Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2006.05.010
Keywords
Theiler's virus; restraint stress; cytokines
Categories
Funding
- PHS HHS [R01 39569] Funding Source: Medline
Ask authors/readers for more resources
Stressful life events have been associated with the onset and/or exacerbation of multiple sclerosis (MS). Our previous studies have indicated that restraint stress (RS) reduces inflammation and virus-induced chemokine expression in the Theiler's virus-induced demyelination (TVID) model of MS. Here we report that RS significantly reduced the virus-induced interferon-gamma mRNA levels in the brain. Additionally, mRNA levels of lymphotoxin-beta, tumor necrosis factor-alpha, and interferon-gamma in the brain were negatively correlated with viral titers in the brain. These results indicated an immunosuppressive effect of stress during early TVID causing impaired viral clearance, which may be a potential exacerbating factor for later demyelination. (c) 2006 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available