Journal
BIOLOGICAL CHEMISTRY
Volume 387, Issue 9, Pages 1219-1226Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2006.151
Keywords
affymetrix; aryl hydrocarbon receptor; CD4 T cells; dendritic cells; Lgals3; scinderin; thymocytes
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The ligand-activated aryl hydrocarbon receptor (AHR) is known to modulate many genes in a highly cell-specific manner, either directly or indirectly via secondary effects. In contrast, little is known about the effects of AHR deficiency on gene expression balance. We compared the transcriptome of CD4 T cells from AHR(-/-) mice and wildtype mice; 390 genes, many of them immunotypic, were deregulated in AHR-deficient CID4 cells. TCDD-induced transcriptome changes correlated with the AHR expression level in immune cells. However, there was little overlap in AHR-dependent transcripts found in T lineage cells or dendritic cells. Our results demonstrate flexible gene accessibility for the AHR in immune cells. The idea of a universal battery of AHR-responsive genes is not tenable.
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