Journal
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
Volume 32, Issue 5, Pages 472-477Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1068162006050104
Keywords
heparin; chemical modification; conjugates; amino-containing compounds; 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide
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Heparin was modified at carboxyl groups by reaction with several pharmacologically important amino-containing compounds in aqueous medium in the presence of 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide. In dependence on the nature of the amine and the ratio of reagents, conjugates containing 36-100% amide and 0-25% isoureidocarbonyl groups were synthesized. Isoureidoarylamide groups are present, along with amide moieties, in the products of heparin modification by hydroxyl-containing aromatic amines. The conjugate of heparin with p-aminobenzoic acid contained oligomeric arylamide.
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