Journal
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
Volume 83, Issue 3, Pages 205-210Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cmpb.2006.04.011
Keywords
SAS (R); constrained randomization; stratified group-randomized trial
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Funding
- NICHD NIH HHS [HD38209] Funding Source: Medline
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Group-randomized study designs are useful when individually-randomized designs either are not possible, or will not be able to estimate the parameters of interest. Group-randomized trials often have small number of experimental units or groups and strong geographically-induced between-unit correlation, thereby increasing the chance of obtaining a bad randomization outcome. It has been suggested to highly constrain the design through restriction to those allocations that meet specified criteria based on certain covariates available at the baseline. We describe a SAS' macro that allocates treatment conditions in a two-arm stratified group-randomized design that ensures balance on relevant covariates. The application of the macro is illustrated using two examples of group-randomized designs. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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