The effect of PEG concentration on the release rate of cisplatin from PEG-modified silica xerogels

Cisplatin-an antineoplastic medicine-was incorporated into a polyethylene glycol (PEG)-modified silica xerogels received by the sol-gel method. The influence of PEG concentration and drying temperature on the release of cisplatin was studied. From our results we may state that addition of PEG (M-W 600) and drying of silica xerogels at 80 degrees C augmented the release of cisplatin. The release of cisplatin from the matrices grows with the increase of PEG volume in xerogel (up to 74-97% within 7 days), whereas application of thermal drying resulted in both increased speed and amount of the drug released up to 91-97% within 2 days.