Journal
JOURNAL OF ANTIBIOTICS
Volume 59, Issue 9, Pages 591-596Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/ja.2006.79
Keywords
paecilaminol; electron transport enzyme inhibitor; NADH-fumarate reductase
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A new NADH-fumarate reductase inhibitor, paecilaminol, was isolated from the cultured broth of a fungus Paecilomyces sp. FKI-0550. It is an amino alcohol compound, the structure being established as 2-amino-14,16-dimethyl-3-octadecanol. Paecilaminol exhibited an IC50 value of 5.1 mu M against Ascaris suum NADH-fumarate reductase.
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