Journal
VETERINARY PATHOLOGY
Volume 43, Issue 5, Pages 777-779Publisher
AMER COLL VET PATHOLOGIST
DOI: 10.1354/vp.43-5-777
Keywords
aging; amyloid; animals; Callithrix; models; neurodegenerative diseases
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The spontaneous incidence and distribution of beta-amyloid (A beta) peptide and argyrophilic deposits were extensively investigated in the common marmoset (Callithrix jacchus). In 12 young marmosets, up to 67 coronal step sections were evaluated in the brain. One brain hemisphere was stained by a silver method and also immunohistochemically with a primary antibody directed against A beta. Argyrophilic deposits were observed in 4 (33%) of 12 animals with silver stain, and A beta was seen in 4 (33%) of 12 animals with anti-4G8 antibody. The overall incidence was 6 (50%) of 12 affected animals. These results show that the young marmoset brain displays A beta deposits at a low incidence and that immunohistochemistry is more suitable than silver staining to reveal rare amyloid plaques. These findings also provide evidence for the early onset of amyloid deposits in marmoset brain.
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