Journal
JOURNAL OF STUDIES ON ALCOHOL
Volume 67, Issue 5, Pages 700-706Publisher
ALCOHOL RES DOCUMENTATION INC CENT ALCOHOL STUD RUTGERS UNIV
DOI: 10.15288/jsa.2006.67.700
Keywords
-
Categories
Funding
- NCRR NIH HHS [M01 RR01070] Funding Source: Medline
- NIAAA NIH HHS [P50 AA1076] Funding Source: Medline
- NIDA NIH HHS [K24 DA00435] Funding Source: Medline
Ask authors/readers for more resources
Objective: Posttraumatic stress disorder (PTSD) is commonly comorbid with alcohol-use disorders. Abnormalities in the bypothalamic-pituitary-adrenal (HPA) axis response are common in both disorders. The objective of this study was to investigate HPA axis reactivity to the cold pressor task (CPT) among individuals with alcohol dependence, PTSD, and comorbid alcohol dependence and PTSD. Method: Participants were 119 individuals with alcohol dependence only (n = 3 1), comorbid alcohol dependence and PTSD (n = 28), PTSD without alcohol dependence (n = 30), and a control group (n = 30). Subjective response, adrenal corticotropic hormone (ACTH), and cortisol were measured before, immediately after, and for 120 minutes after each subject completed the CPT. Results: There were significant group and gender differences found in the subjective and ACTH response, with significantly higher subjective stress ratings and decreased ACTH response in the alcohol-dependent, PTSD, and comorbid alcohol dependent-PTSD groups compared with the control group. Conclusions: There were differences in the HPA axis and subjective response to the CPT between the control group and both the alcohol and PTSD groups. The HPA response in the comorbid alcohol-PTSD group was not significantly different than that of the alcohol-only or PTSD-only groups.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available