Journal
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
Volume 21, Issue 5, Pages 373-384Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911506068554
Keywords
rabbit model; radius; segmental bone defect; nano-hydroxyapatite/collagen/PLA composite; mesenchymal stem cells; fresh-frozen allogeneic bone
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The aim of the present study was to investigate and compare the capacity of fresh-frozen allogeneic bone, nano-hydroxyapatite/collagen/PLA (nHAC/PLA) scaffold, and nHAC/PLA scaffold loaded with bone marrow mesenchymal stem cells (BMSCs) in inducing bone formation. A 10mm segmental rabbit radial defect was surgically created. The animals were divided into four groups in which the defect was either left untreated, or filled with the above-mentioned three grafts. The animals were euthanized at 2, 4, 6, 8, 12, and 18 weeks. Radiographic and histologic analyses were performed on the harvested tissue. We show that nHAC/PLA composite combined with mesenchymal stem cells could enhance and accelerate bone formation in segmental defects of rabbits. nHAC/PLA composite is an ideal bone graft; implanting nRAC/PLA composite combined with mesenchymal stem cells is a potential method for surgical treatment of bone defects.
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