Journal
JOURNAL OF MOLECULAR HISTOLOGY
Volume 37, Issue 5-7, Pages 219-223Publisher
SPRINGER
DOI: 10.1007/s10735-006-9042-9
Keywords
EZH2; breast cancer; DNA repair; homologous recombination; biomarker; prognosis; polycomb; RAD51; RAD51 paralogs; RAD51L1
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Funding
- NCI NIH HHS [K08 CA 090876, R01 CA 107469] Funding Source: Medline
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The Polycomb group protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to tumorigenesis in multiple organs. In this review we summarize the current knowledge on the function of EZH2 in cancer, with special focus on breast cancer, and propose a link between EZH2, the homologous recombination pathway of DNA repair, and breast tumorigenesis.
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