Journal
EXPERIMENTAL PHYSIOLOGY
Volume 91, Issue 5, Pages 803-806Publisher
WILEY
DOI: 10.1113/expphysiol.2006.033498
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Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of HIF-1 alpha and HIF-1 beta subunits that functions as a master regulator of oxygen homeostasis. Oxygen-dependent hydroxylation of HIF-1 alpha provides a mechanism that allows changes in oxygenation to be transduced to the nucleus, leading to changes in gene expression. Hypoxia-inducible factor 1 plays critical roles in development, physiology and disease pathogenesis. Analyses of mice that are heterozygous for a null allele at the locus encoding the HIF-1 alpha subunit have demonstrated that partial deficiency of HIF-1 is sufficient to impair multiple physiological responses to continuous and intermittent hypoxia.
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