Journal
CLINICAL INFECTIOUS DISEASES
Volume 43, Issue -, Pages S49-S56Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/504477
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Funding
- NIAID NIH HHS [AI-0063517] Funding Source: Medline
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Acinetobacter species and Pseudomonas aeruginosa are noted for their intrinsic resistance to antibiotics and for their ability to acquire genes encoding resistance determinants. Foremost among the mechanisms of resistance in both of these pathogens is the production of beta-lactamases and aminoglycoside-modifyingenzymes. Additionally, diminished expression of outer membrane proteins, mutations in topoisomerases, and up-regulation of efflux pumps play an important part in antibiotic resistance. Unfortunately, the accumulation of multiple mechanisms of resistance leads to the development of multiply resistant or even panresistant strains.
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