Journal
INORGANIC CHEMISTRY
Volume 45, Issue 18, Pages 7306-7315Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ic060901u
Keywords
-
Categories
Ask authors/readers for more resources
The tetrahedral cobalt(II) complex [(Tp(Ph, Me)) CoCl] ( Tp(Ph, Me)) hydrotris( 3,5-phenylmethylpyrazolyl) borate) was combined with several hydroxypyridinone, hydroxypyridinethione, pyrone, and thiopyrone ligands to form the corresponding [(Tp(Ph, Me)) Co(L)] complexes. X-ray crystal structures of these complexes were obtained to determine the mode of binding for each ligand L. The structures show that the [(Tp(Ph, Me)) Co( L)] complexes are pentacoordinate complexes, with a general tendency toward square pyramidal geometry. The electronic, EPR, and paramagnetic NMR spectroscopy of the [(Tp(Ph, Me)) Co( L)] complexes have been examined. The frozen-solution EPR spectra are indicative of pentacoordination in frozen solution, while the NMR indicates some dynamics in ligand binding. The findings presented here suggest that [(Tp(Ph,Me)) Co(L)] complexes can be used as spectroscopic references for investigating the mode of inhibitor binding in metalloproteinases of medicinal interest. Potential limitations when using cobalt( II) model complexes are also discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available