Journal
FEBS LETTERS
Volume 580, Issue 20, Pages 4947-4952Publisher
WILEY
DOI: 10.1016/j.febslet.2006.08.012
Keywords
ELAV proteins; oligomerisation; Xenopus oogenesis; RNA binding
Funding
- Wellcome Trust Funding Source: Medline
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We have shown that ElrA and EIrB, Xenopus ELAV homologues, bind the Vg1 mRNA 3'UTR translation element in Xenopus oocytes and implicated ElrB in mediating translational repression during oogenesis. Here we report that, while ElrA and ElrB are 69% identical and both exhibit RNA binding in the nM range, recombinant ElrB, but not ElrA, is able to oligomerise. This oligomerisation is also seen with the endogenous protein. Both RNA binding and oligomerisation require the linker region flanked with two RNA recognition motifs. Our data demonstrate a novel and unique property of ElrB which may be important for its function as a translational regulator. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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