Journal
FEBS LETTERS
Volume 580, Issue 20, Pages 4923-4928Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2006.08.009
Keywords
exocytosis; late endosomes; pseudopod; phagocytosis; macropinocytosis; Dictyostelium discoideum
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Exocytosis of late endocytic compartments in Dictyostelium has mostly been studied by live microscopy. Here we show that this exocytosis is accompanied by a complete fusion of late endosomes with the plasma membrane resulting in the transient formation of membrane microdomains; that can be visualized by immunofluorescence in fixed cells. This permitted to demonstrate that fusion of late endocytic compartments with the cell surface does not occur in regions of the plasma membrane engaged in the formation of pseudopods, macropinosomes or phagosomes. Our results propose that exocytosis of late endosomes and actin-driven membrane remodeling are mutually exclusive processes. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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