Journal
TETRAHEDRON LETTERS
Volume 47, Issue 36, Pages 6409-6412Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.06.135
Keywords
asymmetric; hydrogenation; amines; amides; homogeneous; catalysis
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A mild and efficient route to enantioenriched aryl alkyl amines from ketones has been developed. The first successful synthesis and asymmetric hydrogenation of ene-trifluoroamides from oximes gave highly enantioenriched trifluoroacetamides (94-98% cc). The corresponding phenethyl amides are liberated under mild conditions (K2CO3, MeOH/H2O). In addition, a new application of Josiphos ligands toward the asymmetric hydrogenation of both ene-acetamides and ene-trifluoroacetamides was discovered. (c) 2006 Elsevier Ltd. All rights reserved.
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