Journal
CHEMISTRY LETTERS
Volume 35, Issue 9, Pages 1046-1047Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.2006.1046
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A novel cytoplasmic delivery system of siRNA was developed by complexation between poly(ethylene glycol)-blockpoly(2-(N,N-dimethylamino)ethyl methacrylate) copolymer (PEG-PAMA) and gold nanoparticles (GNPs), followed by the immobilization of siRNA bearing a thiol group (SH-siRNA). The PEGylated GNPs containing SH-siRNA showed a significant RNAi activity in HuH-7 cells.
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