Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 36, Pages 13457-13462Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0604183103
Keywords
imaging; lymphoid organogenesis; transgenic mice
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Funding
- Medical Research Council [MC_U117573801, MC_U117512796, G0601156] Funding Source: Medline
- Medical Research Council [MC_U117512796, MC_U117573801] Funding Source: researchfish
- MRC [MC_U117573801, MC_U117512796] Funding Source: UKRI
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Lymph node (LN) development depends on prenatal interactions occurring between LN inducer and LN organizer cells. We have distinguished defects in LN formation due to failure in embryonic development (aly/aly) from defects in postnatal maturation (Il2r gamma(-/-)Rag2(-/-)). Both mutant strains form normal primordial LNs with differing fate. In aly/aly mice, the LN primordium dissipates irreversibly late in gestation; in contrast, Il2r gamma(-/-)Rag2(-/-) LN anlage persists for a week after birth but disperses subsequently, a process reversible by neonatal transfer of WT IL7r(+) TCR+ T or natural killer (NK) cells, suggesting a role for IL7/IL7r interactions. Thus, we reveal a unique stage of postnatal LN development during which mature lymphocytes and IL7/IL7r interactions may play an important role.
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